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Usual Adult Dose for Rheumatoid Arthritis Immediate-release capsules and suspension: Initial dose: 25 mg orally 2 or 3 times a day Maintenance dose: Adjust dose as needed and tolerated in increments of 25 mg or 50 mg weekly until satisfactory response or maximum dose is achieved Maximum single dose: 100 mg Indomethacin (Indocin) is an NSAID that's used to treat different types of arthritis and conditions that cause pain in the shoulder It helps lower inflammation and relieve pain This form of indomethacin is a suppository that's inserted into the rectum, typically 2 to 4 times a day depending on what condition the medication is being used to Modify Therapy Monitor Closely In vitro studies demonstrated that pretomanid significantly inhibits OAT3; monitor for increased adverse effects and consider dosage reduction for OAT3 substrates probenecid indomethacin will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance May 12, 2022 · INDOCIN SR, 75 mg once a day can be substituted for indomethacin immediate-release capsules, 25 mg three times a day However, there will be significant differences between the two dosage regimens in indomethacin blood levels, especially after 12 hours [see CLINICAL PHARMACOLOGY] In addition, INDOCIN SR, 75 mg twice a day can be substituted People also askJun 11, 2024 · Usual Adult Dose for Rheumatoid Arthritis Immediate-release capsules and suspension: Initial dose: 25 mg orally 2 or 3 times a day Maintenance dose: Adjust dose as needed and tolerated in increments of 25 mg or 50 mg weekly until satisfactory response or maximum dose is achieved Maximum single dose: 100 mg Does Indocin SR cause anemia? 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