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      Is Viagra a generic drug?  Jul 20, 2022 ·     Effects of  VIAGRA  on Other  Drugs   In Vitro Studies  Sildenafil is a weak inhibitor of the CYP isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 > 150 μM)  Given sildenafil peak plasma concentrations of approximately 1 μM after recommended doses, it is unlikely that  VIAGRA  will alter the clearance of substrates of these isoenzymes  In Vivo Studies

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