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People also askEstrace: 1-2 mg PO once daily for 3 weeks, followed by 1 week off Valerate: 10-20 mg IM q4weeks EstroGel: 1 25 g day 3 weeks on, 1 week off Alora, Climara Vivelle-Dot, Estraderm: Use transdermally and follow product-specific directions Prevention of osteoporosis: 0 5 mg PO once daily for 3 weeks, followed by 1 week off May 16, 2023 · The dose depends on why you're taking the medication, and tablets are typically taken 1-3 times a day Some side effects of estradiol include nausea, vomiting, headache, and breast pain The tablet that was once sold as the brand name Estrace has been discontinued, but it's still available as a generic medication What is Estrace tablets? 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